Abstract
A study is made on the effects of repeated intraperitoneal administrations of benzol 0.2cc/kg upon rabbit ERG with the following results:
(1) The amplitude of b wave increases immediately after the administration of benzol and its degree decreases following on repeated administrations.
(2) The amplitude of b wave 48 hours after the administration of benzol gradually decreases following repeated administrations.
(3) The latency of b wave as well as the culmination time of b wave slightly prolongs following repeated administrations.
(4) The amplitude of c wave trends to decrease following repeated administrations.
(5) The above changes of the amplitude in b wave and c wave after repeated administrations of benzol continue for 8 weeks after the discontinuace of the administration of benzol.
(6) The ERG in experimentally bled rabbits does not show remarkable changes which are observed in ERG after the administration of benzol. The development of these changes in ERG following repeated administrations of benzol may be due to a specific action of benzol.
(7) Histologically there are observed a vacuolar degeneration and an atrophy in the retinal nerve fibers as well as in the ganglion cells.
