The Role of l-Methionine and Methylmethionine sulfonium chloride in the Rhythmic Contractions of Atria

Abstract

The influences of l-methionine and methylmethionine sulfonium chloride on the rhythmic contractions of the isolated rabbit and guinea-pig atria were examined.
l-Methionine increased the effects of endogenous and exogenous adrenaline and acetylcholine on the atria, while methylmethionine sulfonium chloride decreased them. It was discussed that l-methionine may be one of the physiologic factors regulating the autonomic functions of atria and methylmethionine sulfonium chloride may interfere in the biochemical and pharmacological actions of l-methionine on the atrial mechanism.