Various Anesthetic Effects on Development of Metastases.

II. Anesthetic Effect on Liver Metastases

Abstract

In the second type of experiment, the rats were anesthetized with each anesthetics, and after 2 hours maintenance 5,000,000 cancer cells (AH 130) in suspension were injected into the portal vein. All animals that survived were sacrificed at 2 weeks and postmortem examinations were made immediately, survival time with the hepatic takes were compared among each anesthetic group.
The chloroform anesthesia had the most harmful effect and hepatic takes were noted in 100 per cent of rats. Penthrane fluothane and ether were next in harmful effect, hepatic takes were noted in 90.9 per cent,81.8 per cent and 80 per cent respectively. When anesthesia with nembutal was performed, takes in the liver were noted in 60per cent of rats.
This indicates that inhalation anesthesia with chloroform, ether penthrane or fluothane acts as a marked stimulus for development of liver metastases.