Effect of Dietary Amino-Acid Imbalance on Cancer Metastases

Part II. Effect of Dietary Amino-Acid Ratio on Cancer Metastases

Abstract

The effect of dietary amino-acid imbalance on the incidence of metastases and local recurrences following tumor removal was investigated.
The results obtained showed that the incidence of metastases and local recurrence or tumor growth followed different patterns among these diets differing only slightly in amino-acid composition; that is, the supplemetation of 5.9 % casein diets with excess isoleucine, methionine and tryptophan (group 4) or excess methionine (group 2) lowered the incidence of metastasis and local recurrence of tumors.
These results suggest that there is an association between altered amino-acid patterns of a diet and metastatic formation or tumor growth. Here, too, the rate of metastatic formation or tumor growth is amazingly sensitive to the amino-acid pattern of a diet. Further exparimentation is necessary to demonstrate the optimal or critical ratio of dietary amino-acids for decreased metastatic formation.