An Electron Microscopic Study on Ferritn from Erytbrocytes Containing Heinz Bodies Phagocytized by Kupffer Cells in Phenylhydrazine-Treated Mouse Liver

Abstract

The present study using perfusion fixation showed the occurrene of ferritin molecules within the Kupffer cells which phagocytized and digested erythrocytes containing Heinz bodies in the liver of the mice given 3 injections of 1 mg or a single injection of 5 mg phenylhydrazine. Evidence was obtained showing a fusion between a small-sized siderosome and a relatively large phagolysosome containing a few amount of ferritin molecules, suggesting an intracellular pathway of iron metabolism in the Kupffer cells. Supplement to J. Kansai Med. Univ., Vol.36, Dec.1984