1984 Volume 36 Issue Supplement Pages s148-s154
Hyperasialoglycoproteinemia in acute liver diseases was studied by the correlation between the amount of serum asialoglycoproteins and results of liver function tests and by measuring the asialoglycoprotein receptor activity in hepatic tissues. Serum asialoglycoproteins accumulated markedly in sera of patients with acute, subacute and fluminant hepatitis. There were significant correlations between asialoglycoproteins level and the values of GOT, GPT and LDH (p < 0.001). The activity of asialoglycoprotein receptor in subacute hepatitis was O.013 U/mg microsomal protein, i. e.,20% of control value (0.064 ± 0.017 U/mg microsomal protein) and the activity in fluminant hepatitis was negligible. These results indicated that a severe liver damage causes the decrease in the receptor activity and an accumulation of serum asialoglycoproteins, and suggested that asialoglycoproteins level could be a good marker of hepatic dysfunction in patients with acute liver diseases.
