3, 3', 5'-Triiodothyronine Inhibits Angiotensin II-Induced Calcium Mobilization and Formation of Inositol 1, 4, 5-Trisphosphate in Vascular Smooth Muscle Cells

Hiroya Masaki; Mitsushige Nishikawa; Masaya Urakami; Mitsuo Inada

doi:10.5361/jkmu1956.46.1-2_4

Hiroya Masaki, Mitsushige Nishikawa, Masaya Urakami, Mitsuo Inada

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Keywords: 3. 3'. 5'-triiodothyronine (rT₃), Angiotensin II, vascular smooth muscle, intracellular calium, inositol 1. 4. 5-trisphosphate (IP₃)

JOURNAL FREE ACCESS

1994 Volume 46 Issue 1-2 Pages 4-9

DOI https://doi.org/10.5361/jkmu1956.46.1-2_4

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Abstract

The effect of 3,3',5'-triiodothyronine (rT₃) on angiotensin II (AII)-induced calcium mobilization and formation of inositol 1,4,5-trisphosphate (IP₃) in vascular smooth muscle cells (VSMC) was studied in this paper. rT₃ at concentrations of 10 and 50,μM inhibited All (1μM)-induced increase in cytosolic calcium concentration ([Ca²⁺]i) and IP₃ formation in VSMC dose-dependently.
These results indicate the possibility that rT₃ which is regarded as an inactive metabolite of thyroxine (T4) has inhibitory effects on vascular smooth muscle function.

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