Abstract
It has been said that there is no effective medicine for critical limb ischemia (CLI). But recently, it is reported that Cilostazol, Beraprost, and Sarpogrelate improve the skin perfusion pressure in patients of peripheral arterial disease. These drugs are expected as an adjunctive medical therapy for CLI. And patients with CLI always have other critical atherosclerosis. We recommend the risk reduction medical therapy for critical atherosclerosis in this report.