抄録
Biomechanical and biochemical factors are
involved in bone remodeling. Occlusal loading is a
well-known mechanical modulator of alveolar
bone remodeling. Neuropeptides, such as vasoactive
intestinal peptide (VIP) and calcitonin generelated
peptide (CGRP), have been described
within the biochemical bone regulators. In this
study, the influences of occlusal loading on the
alveolar bone remodeling and the distribution of
VIP- and CGRP-immunoreactive (IR) fibers were
investigated 1, 3 and 5 days after tooth replantation
in rats. At day 5, occlusal loading induced a significant
increase (p<0.05) in osteoclast number and
osteoblast surface compared to those in the nonoccluded
group. VIP-IR fibers were observed
beside osteoblastic layers and their distribution
was significantly enhanced (p<0.05) at day 5 in the
occluded group, compared to the non-occluded
group. Although there was immunoreactivity for
CGRP in the periodontal ligament and alveolar
bone apically, CGRP-IR fibers were not detected
above the furcation. These results suggest that,
after tooth replantation in rats, occlusal loading
induced an increase in osteoclast and osteoblast
formation, and that VIP might play a functional role
in osteoblasts.
