2018 年 65 巻 4 号 p. 139-148
Background: This study aimed to elucidate the prognostic value of texture analysis on positron emission tomography/computed tomography in indolent B-cell lymphoma patients who received chemoimmunotherapy followed by rituximab maintenance therapy. Methods: Twenty-two patients with pathologically proven indolent B-cell lymphoma underwent 18 F-flu o ro d e ox yglu c o s e p o sit ro n e mis sio n tomography/computed tomography at study enrollment, after induction therapy, after rituximab maintenance therapy, and at post-rituximab maintenance follow-up period. Textural parameters at baseline were evaluated from volume of interest. Texture features included 12 higher-order features, 5 second-order features, and 7 firstorder features. Percentage reduction rates of the standardized uptake value parameters between baseline and post-rituximab maintenance therapy were calculated. Stratification of texture features and standardized uptake value parameters were compared with progression-free survival using the Mantel-Cox log-rank test. Results: The decreased percentage changes in all standardized uptake value parameters showed significant differences with prognosis by univariate analysis (P＜0.01). Neighborhood grey tone difference matrices strength, neighborhood grey level co-occurrence matrices (NGLCM3D) homogeneity-max, and NGLCM3D mean uniformity were significantly different with prognosis (P＝0.03). Conclusion: These results suggest that texture features of positron emission tomography/ computed tomography are potential prognostic indicators in patients with indolent B - cell lymphoma.
