Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice

Nunuk Purwanti; Ahmad Azlina; Mileva R Karabasil; Takahiro Hasegawa; Chenjuan Yao; Tetsuya Akamatsu; Kazuo Hosoi

doi:10.2152/jmi.56.253

Development, Regeneration, and Tissue Engineering of the Glandular Tissue

Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice

Nunuk Purwanti, Ahmad Azlina, Mileva R Karabasil, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Kazuo Hosoi

著者情報

キーワード: submandibular gland, IL-6, STAT3, duct-ligation

ジャーナルフリー

2009 年 56 巻 Supplement 号 p. 253-254

DOI https://doi.org/10.2152/jmi.56.253

詳細

抄録

Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway. J. Med. Invest. 56 Suppl.: 253-254, December, 2009

責任著者(Corresponding author)

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