Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

Delgerdalai Khashbat, MD; Takashi Abe, MD; Mungunbagana Ganbold, MD; Seiji Iwamoto, MD; Naoto Uyama, MD; Saho Irahara, MD; Youichi Otomi, MD, PhD; Masafumi Harada, MD, PhD; Teruyoshi Kageji, MD, PhD; Shinji Nagahiro, MD, PhD

doi:10.2152/jmi.63.175

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Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

Delgerdalai Khashbat, MD, Takashi Abe, MD, Mungunbagana Ganbold, MD, Seiji Iwamoto, MD, Naoto Uyama, MD, Saho Irahara, MD, Youichi Otomi, MD, PhD, Masafumi Harada, MD, PhD, Teruyoshi Kageji, MD, PhD, Shinji Nagahiro, MD, PhD

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Keywords: magnetic resonance imaging, arterial spin labeling, dynamic susceptibility contrast perfusion, time to maximum, brain tumor

JOURNAL FREE ACCESS

2016 Volume 63 Issue 3.4 Pages 175-181

DOI https://doi.org/10.2152/jmi.63.175

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Abstract

Purpose: Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Methods: Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. Results: ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. Conclusions: ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor. J. Med. Invest. 63: 175-181, August, 2016

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