Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease

Akira Takashima; Shusuke Yagi; Koji Yamaguchi; Kiyoe Kurahashi; Yuko Kojima; Robert Zheng; Takayuki Ise; Kenya Kusunose; Sumiko Yoshida; Hirotsugu Yamada; Takeshi Soeki; Tetsuzo Wakatsuki; Ken-ichi Aihara; Masashi Akaike; Masataka Sata

doi:10.2152/jmi.68.189

Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Masataka Sata

Author information

Akira Takashima
Department of Cardiovascular Medicine, Kitajima Taoka Hospital, Tokushima, Japan
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Shusuke Yagi
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Koji Yamaguchi
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Kiyoe Kurahashi
Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Science, Tokushima, Japan
Yuko Kojima
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Robert Zheng
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Takayuki Ise
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Kenya Kusunose
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Sumiko Yoshida
Department of Haematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Science, Tokushima, Japan
Hirotsugu Yamada
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Takeshi Soeki
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Tetsuzo Wakatsuki
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
Ken-ichi Aihara
epartment of Community Medicine for Diabetes and Metabolic Disorders, Tokushima University Graduate School of Biomedical Science, Tokushima, Japan
Masashi Akaike
Department of Medical Education, Tokushima University, Tokushima, Japan
Masataka Sata
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan

Keywords: congenital hypogonadotropic hypogonadism, coronary artery disease, diabetes mellitus, Kallmann syndrome, testosterone

JOURNAL FREE ACCESS

2021 Volume 68 Issue 1.2 Pages 189-191

DOI https://doi.org/10.2152/jmi.68.189

Details

Abstract

The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021

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