1993 Volume 11 Pages 1-10
The urinary bladders of dogs were irradiated experimentally with microwaves in order to examine thermal distribution and histological changes after microwave irradiation. A clinicopathological evaluation was also performed using bladder cancer specimens treated by microwave coagulation therapy. The present study indicates that microwave coagulation therapy is a safe and useful procedure for the local control of muscle-infiltrating bladder cancer for the following reasons: 1) Perforation of the bladder wall is not required to conduct this therapy. 2) The thermal effects of microwaves that spread through the profound portion of the muscle layer of the bladder result in sufficient necrosis. Degeneration with pyknosis of nuclei was observed in the peripheral region. Three months after microwave coagulation, granulation formed; 6 months after microwave coagulation, the coagulated region became scarred.
