抄録
We investigated the effects of magnetic fields on the enzymatic activity of plasmin with respect to the dissolution of thrombosis. Plasmin activity in magnetic fields up to 8 T was assessed by using a synthetic substrate for plasmin, D-Val-Leu-Lys-pNA. We observed that the initial rate of the reaction accelerated by 5% in an 8 T magnetic field. We also measured the time courses of the reaction. When the absorbance changed non-linearly and reached 60-90% of the maximum absorbance, the absorbance of the mixture exposed to an 8 T magnetic field at 37°C was 7-11% lower than in control samples. The results show that the enzyme reaction of a plasmin with a synthetic substrate was affected by a magnetic field at 8 T, with a consequent inactivation of the enzymatic activity was observed.
