論文ID: JNMS.2021_88-108
To date, the efficacy and safety of the use of antipsychotics in children and adolescents have not been fully established. Although approved for use in adults, many antipsychotics are prescribed to children and adolescents in an off-label manner, at the discretion of individual physicians. This study aimed to identify the efficacy and tolerability of different antipsychotics in children and adolescents with schizophrenia or bipolar disorder. We conducted a literature review of the empirical evidence for the use of antipsychotics, particularly second-generation antipsychotics, in children and adolescents. The empirical evidence showed that antipsychotic use among children and adolescents was safe and efficacious. The efficacy of antipsychotics in the treatment of children and adolescents with schizophrenia or bipolar disorder was almost similar. When prescribing antipsychotics to children and adolescents, clinicians should consider adverse events and/or the discontinuation rate in treated patients. However, based on current evidence, it appears difficult to reach a consensus on the use of antipsychotics in children and adolescents.
