Abstract
Effects of blood pH on the kinin system were studied fundamentally and clinically. Bradykinin was measured by bioassay of Miyanaga's method, and bradykininase was measured by bioassay of Streeten's method. Fundamental study showed that bradykinin recovery was 2.5 times higher in rabbits of acidosis than in rabbits of normal condition. However, there was not a significant difference in bradykinin recovery between rabbits of alkalosis and normal rabbits. Bradykininase in rabbits of acidosis was dropping, but in rabbits of al kalosis was slightly elevating. These facts suggest that bradykinin is very sensitive even to a little fluctuation of pH in the blood, but bradykininase might be hardly influenced even by pH of 7.0 in the blood. On the other hand, from the clinical point of view, the patients with Behcet disease were found to be acidosis, and bradykinin activity was slightly high, but bradykininase activity was low.
In patients with diabets mellitus, there was not a significant differences between activities of bradykinin or bradykininase, and pH. In patients with myocardial infarction with strong acidosis, values of both bradykinin and bradykininase were high.
