抄録
The purpose of this study is to describe the effects of a hypertonic solution of glycerol on raised intracranial pressure (ICP) by epidural pressure recordings of 45 postoperative patients.
These cases included 23 cerebral aneurysms, 14 brain tumors, 6 hypertensive intracerebral hemorrhages and 2 cerebral contusions. Glycerol was prepared as 10% solution, in which 5% fructose was added as an antihemolysis agents. Two groups were classified by the infusion dosage and the rate of glycerol. Group A : 0.5 g/kg of glycerol infused within 30, 60 and 90 minutes. Group B: 1.0 g/kg of glycerol infused within 60, 120 and 180 minutes.
Results
1) When glycerol solution was administered, over 23% reduction of ICP was observed in both groups as compared with the average of the initial ICP levels. The slower the infusion rate, the lower was the level of ICP.
2) In both groups, the slower the infusion rate of the same dosage of glycerol solution, the longer the reduction time of ICP lasted.
3) A rebound phenomenon was found in about 38% of all administered cases. However, the rebound phenomenon was found in less than 20% when glycerol was infused within 30 minutes in group A and infused within 120 minutes in group B. On the other hand, the rebound phenomenon was found in more than 50% when infused within 60 minutes in group A and infused within 180 minutes in group B.
It was concluded that the optimal dosage and the rate of glycerol infusion was 1.0 g/kg within 120 minutes.
