Abstract
The effect of TRH on gastric antral motor activity was examined in human subjects. Antral motor activity was assessed by balloon-kymography and electromyography (EMG). A balloon and an electrode were introduced into the gastric antrum through 2 channel fiberscope. When TRH was administered iv bolus at a dose of 250 or 500μg, gastric peristalsis was completely inhibited for 5-10min. Time of occurrence of rhythmic contraction during recovery was not modulated by previous TRH injection. When TRH was infused iv at a rate of 4μg/min, gastric peristalsis was inhibited completely for as long as the subjects were receiving TRH. Reinfusion of TRH after a short period of cessation similarly inhibited gastric peristalsis. The inhibitory effect of TRH on gastric motor activity was also confirmed by endoscopy and polysogram of the stomach.
These results demonstrate that TRH administered iv exerts a potent inhibitory effect on gastric motor activity in human subjects and that the phenomenon of desentization and/or tachylaxis were not observed. Thus, TRH can be considered a useful adjunct to endoscopic and roentgenographic examinations of the stomach.
