抄録
This study was designed to clarify the morphological features of the extra-cellular matrix and patterns of the neovascularization in gastric cancer in virtue of the histopathological and immunohistochemical methods. Abundant proliferation of collagen fibers and reticulum fibers as well as increased glycosaminoglycan was confirmed in the intra-mucosal invasive portion of the poorly differentiated adenocarcinoma in comparison with the similar portion of the well differentiated adenocarcinoma.
The mesenchymal components which were composed of the collagen and reticulum fibers were abundant in the invasive portion, compared to the intra-mucosal tumorous portion.
The immunohistochemical study disclosed dispersed positive reaction to the fibronectin in the stroma and positive reaction to the Factor VIII in the vascular wall in the well differentiated adenocarcinoma.
The findings differed from the ones observed in the poorly differentiated adenocarcinoma which disclosed pleomorphic vascular endothelial cells with large nuclei and incomplete formation of the basal lamina, demon-strating different immunohistochemical features.
Thus it is concluded that the extent of differentiation of the cancer may be closely related with the patterns of extra-cellular matrix and neovascularization.
The interacting pattern of the matrix and cell perse may be also well correlated with the tumor growth in gastric cancer.
