Journal of Nursing Science and Engineering
Online ISSN : 2432-6283
Print ISSN : 2188-4323
Original Articles
Factors associated with severe skin disorder after extravasation of intravenously infused antineoplastic agents
Yuko MatsuiRyoko MurayamaHidenori TanabeMakoto OeYoshiharu MotooTakanori WagatsumaMichiko MichibuchiSachiko KinoshitaKeiko SakaiChizuko KonyaJunko SugamaHiromi Sanada
Author information

2018 Volume 5 Issue 1 Pages 31-40


 This study examined factors associated with severe skin disorders after extravasation. Among 256 patients who received intravenous drip infusion of antineoplastic agents from April through September 2014, the 25 patients who experienced extravasation were analyzed. Measurements of skin temperature by thermography and macroscopic observation were performed during drip infusion to each patient. The severe group(12 patients)was defined as patients showing induration or blistering at the next hospital visit. The remaining 13 patients constituted the mild group. Various factors were compared between groups. All study protocols were approved by the Kanazawa Medical University Ethics Committee. The severe group was characterized by longer administration of vesicant or irritant agents after appearance of a thermographic low-temperature region suggesting extravasation(severe group, 28 min;mild group, 6 min;P=0.017), lack of swelling during administration(severe group, 92%;mild group, 46%;P=0.03), and lower age(severe group, 59.4 y;mild group, 71.2 y;P=0.037). The results of the present study suggest that the factor associated with severe skin disorder after extravasation was a long duration of extravasation due to a lack of recognition of swelling after the first appearance of symptoms.

Information related to the author
© 2018 The Society for Nursing Science and Engineering
Previous article Next article