Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
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Genistein Suppresses Development of Spontaneous Atopic-Like Dermatitis in NC/Nga Mice
Tohru SAKAIMari KOGISOKaori MITSUYATatushi KOMATSUShigeru YAMAMOTO
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2006 Volume 52 Issue 4 Pages 293-296

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Abstract

In this study, we examined the effect of genistein on the severity of dermatitis and level of serum IgE in NC/Nga (NC) mice. NC mice housed in conventional conditions develop spontaneous atopic-like dermatitis; however, oral administration of 20 mg/kg genistein suppresses the development of dermatitis. We also investigated the levels of serum IgE in genistein-treated NC mice and found that the levels were the same as those in control NC mice. We further investigated in vitro IFN-γ and IL-4 production from spleen cells upon stimulation with anti-CD3 and anti-CD28 mAbs. IFN-γ production level in NC mice that received 20 mg/kg genistein was significantly lower than that in control NC mice. In contrast, the production level of IL-4 in genistein-treated mice was not significantly different from that in control mice but tended to increase in a dose-dependent manner.

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© 2006 by the Center for Academic Publications Japan
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