Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Regular Paper
Oral Administration of Acidic Xylooligosaccharides Prevents the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
Takayuki OHBUCHIMakoto SAKAINOTetsunari TAKAHASHINaoya AZUMIKotaro ISHIKAWASadahiro KAWAZOEYukiko KOBAYASHIYasuhiro KIDO
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2010 Volume 56 Issue 1 Pages 54-59

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Abstract

We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.

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© 2010 by the Center for Academic Publications Japan
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