Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Regular Paper
Anti-Inflammatory Effects of Seeds of the Tropical Fruit Camu-Camu (Myrciaria dubia)
Kazunaga YAZAWAKatsumi SUGAAtsushi HONMAMiyuki SHIROSAKITomoyuki KOYAMA
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2011 Volume 57 Issue 1 Pages 104-107

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Abstract

The methanolic extract of seeds of the tropical fruit camu-camu was screened for its anti-inflammatory activity in carrageenan-induced paw edema model mice. The extract significantly suppressed both the formation of edema in mice by oral administration and the release of nitric oxide from macrophage-derived RAW 264.7 cells in vitro. Based on the results of a spectroscopic analysis, the active compound was identified by in vivo bioassay-guided fractionation to be 3β-hydroxy-lup-20(29)-en-28-oic acid, betulinic acid, known as an anti-inflammatory triterpenoid. These findings suggest that camu-camu seed extract is a potentially useful material as a source of betulinic acid and as a functional food for prevention of immune-related diseases.

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© 2011 by the Center for Academic Publications Japan
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