THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
EFFECT OF ACETOACETATE AND β-HYDROXY-BUTYRATE ON THE BIOSYNTHESIS OF NIACIN FROM TRYPTOPHAN
N. V. SHASTRIS. G. NAYUDUM. C. NATH
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1967 Volume 13 Issue 1 Pages 47-51

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Abstract
The ketone bodies, acetoacetate and β-hydroxybutyrate, when admistered to niacindeficient rats along with tryptophan, inhibited the synthesis of niacin from tryptophan. Prolonged administration of the ketone bodies to rats on normal diet, induced a metabolic defect, which inhibited the synthesis of niacin from administered trypotophan. Administration of acetoacetate and β-hydroxybroxybutyrate for seventy-five days considerably decreased the niacin contents of blood, liver and muscle.
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© THE VITAMIN SOCIETY OF JAPAN
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