Abstract
AICA and AICA orotate were given in massive doses together with 20% casein diet to rats with liver injuries induced by a low protein, amino acid imbalanced diet, and the effects of both agents appraised.
AICA orotate was apparently of value in recovering iodine numbers of fatty acids in liver lipids, increasing Palade granules and inhibiting fibrosis. Given in optimum doses, both agents may exhibit further effects.
AICA was effective in repairing cell necrosis but had rather an inhibitive effect on the recovery of fibrosis.
It is advisable not to use AICA alone to prevent metabolic unbalance of nucleic acids.
