Influence of Thiamine on Protein Biosynthesis

Abstract

The incorporation experiments with labeled serine in the crude microsomal protein fraction of normal and thiamine deficient rat liver were carried out. The liver microsomal fraction of animals kept on the thiamine deficient diet showed less incorporation of lebeled serine than the normal animals.
The injection of thiamine in the thiamine deficient animals two hours before killing increased to an appreciable extent the incorporation of labeled serine in microsomal protein, indicating a possible role of thiamine in protein biosynthesis.