THE INHIBITORY EFFECT OF PYRIDOXAMINE UPON THE DEVELOPMENT OF RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS VAR. AVIUM TO STREPTOMYCIN

Abstract

1. Pyridoxamine markedly inhibited the development of resistance to streptomycin of avian tubercle bacilli.
2. No effective substance capable of reversing the resistance of the streptomycin-resistant bacilli was found.
3. No difference in virulence was observed among the sensitive strain, the strain in which the aquisition of streptomycin resistance had been inhibited by adding PAM, and the 1000γ/ml streptomycin-resistant strain.