1976 Volume 22 Issue 2 Pages 79-87
The in vivo utilization of D-[U-14C] glucose with particular reference to its incorporation into brain and liver proteins was studied in biotin-deficient rats. The data show a significant reduction in the incorporation of glucose carbon into brain and liver proteins. A disturbance in the intermediary metabolism of glucose appears to be one of the factors responsible for the decreased incorporation of the label into proteins in biotin deficiency.