Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
EFFECT OF NIACIN DEFICIENCY ON THE METABO-LISM OF BRAIN AMINES IN RATS
Hiroo SANADAYoko NAKASHIMAYoshio UTSUKIShoji KAWADA
Author information
JOURNAL FREE ACCESS

1978 Volume 24 Issue 2 Pages 159-166

Details
Abstract
The effect of niacin deficiency on the activities of tyrosine hydroxylase and tryptophan-5-monooxygenase was studied in relation to the contents of catecholamines and serotonin in brain to clarify the role of the vitamin in brain function. Male rats 4 weeks of age were fed a niacin-free, low-protein diet for 3 weeks. Tests for the avoidance learn ing behavior were started at 14 th day in experimental period and were repeated 3 times every other day. After sacrifice on the 21st day, the activities of tyrosine hydroxylase and tryptophan-5-monooxygenase in the brain homogenates were assayed. In the other experiments, contents of dopamine, norepinephrine and serotonin in brain were determined in rats fed on the same niacin-deficient, low-protein diet for 3 weeks. The activity of crude tyrosine hydroxylase in brain was found to be increased significantly in niacin deficiency and was reduced below that of the control one week after niacin supplementation to the deficient rats. On the contrary, contents of dopamine and norepinephrine in whole brain of the niacin-deficient rats showed a significant decrease. No significant dif ference in brain tryptophan-5-monooxygenase activities was observed among niacin-deficient, low-protein control and normal commercial diet groups. Brain serotonin contents of the niacin-deficient animals were almost the same as that of the low-protein control, but were less than that of the rats fed on niacin-supplemented 20% casein diet. Though, no significant difference was observed between the learning abilities of niacin deficient and control groups, these results suggested that the change of catecholamine and serotonin metabolism in brain was one of the causes for some malfunction of the central nervous system induced by niacin deficiency.
Content from these authors
© the Center for Academic Publications Japan
Previous article Next article
feedback
Top