CENTRALLY MEDIATED HYPERGLYCEMIA BY 6-AMINONICOTINAMIDE

Abstract

Some metabolic changes induced by the intraventricular administration of 6-aminonicotinamide (6-AN) were studied in mice. Five or ten μg/animal of 6-AN produced a marked hyperglycemia, lowered glycogen content in the brain and liver, and reduced the adrenal epinephrine content. Adrenalectomy or hexamethonium prevented 6-AN induced hyperglycemia and decrease of glycogen content in the liver but not in the brain. Decrease of adrenal epinephrine content induced by 6-AN was overcome by hexamethonium. Pretreatment with 6-AN (10 /μg/animal) markedly lowered the toxic action, but not the hypoglycemic action, of a large dose of insulin.