2000 Volume 46 Issue 3 Pages 141-143
Using a vitamin E mixture extracted from palm oil, the tissue distribution of dietary tocotrienols and tocopherols was examined in rats and mice. Wistar rats (4-wk-old) were fed a diet containing 48.8mg/kg a-tocopherol, 45.8mg/kg a-tocotrienol and 71.4mg/kg γ-tocotrienol for 8 wk. Nude mice (BALB/c Sic-nu, 8-wk-old) and hairless mice (SKH1, 8-wk-old) were fed the same diet for 4 wk. α-Tocopherol was abundantly retained in the skin, liver, kidney and plasma of rats and mice. α-Tocotrienol and γ-tocotrienol were de-tected slightly in the liver, kidney and plasma, while substantial amounts of these to-cotrienols were detected in the skin of both rats and mice. The present study suggests that the skin is a unique tissue in respect to its ability to discriminate between various vitamin E analogs.