2002 Volume 48 Issue 2 Pages 161-164
To evaluate the effects of long-term voluntary resistance exercise (climbing) compared with aerobic exercise (swimming) on iron status in severely (4mg Fe/kg diet) and mildly (18-29 mg Fe/kg diet) iron-deficient rats, we trained male Wistar rats for 8 wk to climb a wire-mesh tower (∅20cm×200cm, CLIMB) and to swim in a plastic pool (∅50cm×50cm, SWIM). These rats were compared with sedentary (SED) rats. After the experimental period, blood hemoglobin level, plasma iron concentration, and transferrin saturation were significantly lower in the 4mg Fe/kg diet rats than in the 18, 29, and 40mg Fe/kg diet rats. In 4mg Fe/kg diet rats, the hemoglobin level was significantly higher in the CLIMB group than in the SED and SWIM groups. On the other hand, neither exercise affected iron status in mildly iron-deficient rats. Bone marrow δ-aminolevulinic acid dehydratase activity was significantly higher in the CLIMB group than in the SWIM and SED groups. These results suggest that long-term resistance exercise is more effective than aerobic exercise in improving blood hemoglobin concentration in severely iron-deficient rats, probably because of an increase in heme biosynthesis. Resistance exercise may be a useful therapy for iron-deficient anemia.