Abstract
The effects of proanthocyanidin-rich extract in rats subjected to renal Ischemia-reperfusion were examined. Proanthocyanidin-rich extract, which is prepared from grape seeds (Vitis vinifera L.), was given orally at doses of 5 and 10mg/kg body weight/ d for 20 consecutive days prior to Ischemia-reperfusion. Administration of proanthocyanU din-rich extract attenuated renal dysfunction, as indicated by serum urea nitrogen and creatinine levels. Additionally, in the ischemic-reperfused kidneys, increased levels of thiobarbituric acid (TBA)-reactive substance and alterations of antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase (GSH-Px) were observed. Proanthocyanidin-rich extract-treated groups showed significantly reduced renal TBA-reactive substance levels and enhanced catalase and GSH-Px activities, These results suggest that proanthocyanidin-rich extract has protective effects against Ischemia reperfusion-induced renal damage associated with oxidative stress.
