Journal of Clinical Physiology
Online ISSN : 2435-1695
Print ISSN : 0286-7052
Original Paper
Long-term Systolic Blood Pressure Variability Promotes a Decline in the Renal Function in Middle-aged and Older Males
Ryoma MICHISHITATakuro MATSUDAYoshinari UEHARANatsumi MORITOTakanobu NIIYasuki HIGAKI
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JOURNALS OPEN ACCESS

2019 Volume 49 Issue 3 Pages 143-150

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Abstract

 Background: This study was designed to investigate the association between long-term systolic blood pressure (SBP) variability and the decline in the estimated glomerular filtration rate (eGFR).

 Methods: The subjects included 303 males without renal dysfunction or dialysis treatment. SBP variability was defined as the standard deviation (SD) from their periodic health checkup data at seven consecutive visits.

 Results: The eGFR decline was found to be significantly associated with an increase in the SD of SBP. In addition, the eGFR decline in the combined high SD of SBP and high average SBP group was significantly greater in comparison to other groups.

 Conclusions: These results suggest that the longterm SBP elevation and its variability may be associated with the prevention of a decline in the renal function.

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© 2019 Japanese Society of Clinical Physiology
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