Relationship between Carotid Intima-media Thickness and Onset of Dementia Onset in Type 2 Diabetes Patients

Abstract

　Background: It has been reported that the incidence of dementia is higher in patients with type 2 diabetes, and that the arteriosclerosis index score is a predictor of the onset of dementia in this group.

　Purpose: The purpose of this study was to investigate whether carotid intima-media thickness (IMT) was a predictor of the onset of dementia in type 2 diabetes patients.

　Method: Max IMT was determined by carotid artery echo and the Hasegawa Dementia Rating Scale-Revised score obtained in 85 type 2 diabetes outpatients who were followed for an average of 4.7 years. Dementia was newly diagnosed in 15 of this group. The contributing factors for onset of dementia were determined by multivariable logistic analysis.

　Results: Age, male sex, presence of cardiovascular disease, and max IMT (Odds Ratio: 5.515, 95％ CI: 1.408−10.000, p＝0.005) were identified as contributing factors in the onset of dementia in patients with type 2 diabetes.

　Conclusion: The present results suggest that there is a relationship between carotid IMT and the onset of dementia in type 2 diabetes patients.