2023 Volume 53 Issue 5 Pages 125-131
Background: The pathogenesis of hyperuricemia in the working generation remains to be clarified.
Objectives and Methods: This study investigated change in various cardiovascular risk factors by job category, treatment effect, and their mutual relationship using the following 3 cohorts: (1) 2813 employees with normal uric acid levels in 2010 for whom regular health checkup data from 2010 to 2020 could be compared (multivariate analysis group); (2) 322 patients with 7.0 mg/dL or more in both 2010 and 2020 (sustained group); and (3) 432 patients with 7.0 mg/dL or higher in 2010 and normal in 2020 (improved group).
Results: Using under treatment and/or untreated hyperuricemia as the endpoint in 2020, the odds ratios in 2010 for obesity, hypertension, and chronic kidney disease showed significant elevation, while showing a significant reduction for diabetes in multivariate analysis. In the sustained group, eGFR was significantly reduced. On the other hand, no reduction in eGFR and a significant reduction in blood pressure and LDL-C were observed in the improved group. No differences were observed by job category.
Conclusion: Analysis of the pathogenesis and progression of hyperuricemia revealed that its onset and persistence was linked to chronic kidney disease and associated with obesity and hypertension. These changes could be prevented by early intervention.
