Morphological influence of osteoporosis and bisphosphonates on rat maxillary gingiva
2021 年 55 巻 1 号 p. 27-33
詳細
2021 年 55 巻 1 号 p. 27-33
We investigated the morphological influence of bisphosphonates on the rat maxillary gingiva using an ovariectomized osteoporosis model rat. Eight-week-old female Wistar rats were divided into osteoporosis and sham surgery groups; both groups underwent bilateral ovariectomy and laparotomy. After surgery, they were separated into either bisphosphonate or normal saline treatment groups. One week after completing treatment, all rats were euthanized, and the maxilla and mucosa were removed. No differences existed among the groups in the thickness of the mucosal epithelium or cell population in the granular and prickle layers. On the other hand, the cross-sectional area of the connective tissue beneath the mucosal epithelium and the diameter of the gingival capillaries were significantly smaller in the bisphosphonate groups than in the normal saline groups. The morphology of the microvascular network was regular and rectangular in the normal saline groups, but irregular and elliptical in the bisphosphonate groups. Although osteoporosis alone had no affect on the maxillary gingiva or microvascular architecture, bisphosphonate potentially caused microangiopathy and atrophic changes in this tissue. Thus, it is important to consider the morphological influence of bisphosphonate on tissues beneath the gingival mucosa and on the gingival microvascular architecture. (J Osaka Dent Univ 2021; 55: 27-33)
