New exploration method for custom synthesis

—Establishment of investigational new drug intermediate database system—

Abstract

For the business of custom synthesis in fine chemicals, the new efficient intermediate database system has been established. Using the database, the new exploration method of investigational new drugs (IND) has been studied in order to apply company chemicals. The database consists of INDs derived from the commercially available databases, and the corresponding intermediates extracted from Chemical Abstracts (CA). By performing the new database system with a query substructure, the concrete intermediates and the corresponding INDs have been found. The article reports how to generate, the contents and advantage of the database.