A contribution to the anaphylactic fever. I. Report

Abstract

Friedberger-Mita suggested from the point of view of their own experiments on the anaphylactic fever, that the infections-fever is nothing other than the anaphylactic fever. They recognized a certain relation between the body temperature of a test animal and the to it paraenteral brought foreign protein dose and the far greater sensitiveness of the temperature reaction thereby in the sensitized case than in the non-sensitized. Farther, could they make arbitrarily after various fever-curve characteristic to the infections-fever by means of the paraenteral foreign protein reinjections those were repeated under the proper arrangement of dosage and interval.
The author overexperimented with their work, and farther researched after the influence of the function of the reticulo-endothelial-system (R. E. S.) upon the anaphylactic fever and the changes of both praecipitin- and komplement-titre thereby.
As test animal guinea-pig, as antigen goat-serum was employed and as the blocking material of the R. E. S. Indian-ink was used.
The following conclusions may be derived from our own experiments.
1) By the non-sensitised animal, in the case, that which R. E. S. thoroughly has been blocked, are so-called border-doses markedly reduced.
2) The temperature of the sensitised animal reacts far more sensitive upon the paraenteral foreign protein injection than that of the non-sensitised as Friedberger-Mita stated. Thereby is the anaphylactic-index promoted, when man blocks the functions of the R. E. S. before end-injection and decreased, when man blocks it direct before sensitising-injection.
3) Man can arouse each type of fever in the sensitised animals by means of the repeated end-injections as Friedberger-Mita stated. Thereby, the praecipitin- and the komplement-titre in serum in general parallely reduce in the stadium of fever-rising, and when they have diminished to a marked degree, does the fever neither continue nor newly arise.
By the sensitised animals, those R. E. S. have been blocked direct before end-injection, man can neither make after various fever types so freely nor find so marked changes of the praecipitin- and the komplement-titre thereby as the normal sensitised animals.