1956 Volume 68 Issue 11supplement Pages 45-58
It is widely known that the Japanese B encephalitis virus invades not only the central nervous system, but also various visceral organs. Among them the liver is the greatest organ, and the metabolism in liver is especially important to organism. Therefore I studied the oxygen consumption and aerobic, anaerobic glycolysis of liver tissues from mice inoculated with Jap. B encephalitis virus by means of Warburg's manometric method; and the following results were obtained:
1. The rates of aerobic, anaerobic glycolysis of liver tissues from mice inoculated with Jap. B encephalitis virus decrease remarkably after seventy two hours after virus inoculation, but the respiration is not impaired at this stage.
2. The Jap. B encephalitis virus impairs glucose utilization of the tissues of the organism, in which the virus invaded, and this impairment causes general ketosis, which is considered to be a cause of salicylaldehyde reaction.
3. The Jap. B encephalitis virus has no iufluence on Pasteur's ferment in mouse liver.
4. Types of mouse liver metabolism, which are classified by Meyerhof's quotient, Warburg's quotient and fermentation excess, are not altered even after the Jap. B encephalitis virus infection.
