癌浸出液の膵に及ぼす影響について
(第2編) 膵内分泌に及ぼす影響について
1956 年 68 巻 8special 号 p. 57-71
詳細
1956 年 68 巻 8special 号 p. 57-71
Insulin was extracted by the Sulfric acid-Alcohol method (Kumagaya) from the pancreatic tissue of dogs which were given 10% cancer tissue extract 1 cc/kg daily intravenously for various periods.
The amount of the extracted insulin was measured by the Toronto method using rabbits.
The following results were obtained;
1) The amount of insulin in the pancreas obviously decreased by the injection of cancer tissue extract compared to the control group.
2) Insulin began to decrease 1 week after the daily intravenous injection of cancer extract. The decrease was moderate after 2 weeks and marked after 4 weeks.
Pancreatic tissue of rabbits, which were given 10% cancerous extract 1 cc/kg daily intravenously, was studied histologically by Chromium Hematoxylin-Phroxin stain.
The following results were obtained;
1) It was found that the number of islets decreased; the size of islet became smaller; and the number of β-cells diminished.
Degenerative changes were found in the islets and β-cells after the daily intravenous injection of cancer tissue extract.
2) These changes were noticeable 1 week after the daily injection; moderate after 2 weeks; and marked after 4 weeks.
It is believed that the function of the internal secretion of the pancreas is inhibited by injection of cancer tissue extract.
