1957 年 69 巻 12 号 p. 2957-2968
As a pipe to drain blood which accumlated in the thoracic cavity after resection of the lung, a tube of Dow Couning Silastic 50 & 80 (0.8 cm in inside diameter, 1.5 cm in outside diameter and 90 cm in length) was made for trial. And the toxicity of Silicone rubber was examined and compared with that of Nelaton's rubber and vinyl.
1) Forty-eight to seventy-two hours after the resection the drainpipes were removed and tissues which were found at the tips of them were examined.
2) Silicone rubber was implanted under the fascia of 12 dogs. The local histological changes were examined after 2 to 4 weeks, and compared those of Nelaton's rubber and vinyl.
3) They were respectively implanted in the thoracic cavities of 15 dogs. After 3 to 4 weeks the cavities were reopened and the findings observed. All examination stated above revealed the toxicity and irritating action of vinyl and Nelaton's rubber were strong while Silicone rubber had no toxicity at all. The Silicone rubber drainpipe was clinically applied to about 100 cases. The result was exellent and no occlusion by clotted was experienced by the time the drainpipe was drawn out 72 hours after operation. A statistical comparison of chest X-ray films which were taken 7 days after operation disclosed that better results could be obtained with Silicone rubber drainpipe than with Nelaton's catheter and stomach drainpipe.