放射性同位元素³²Pによる脳の燐酸代謝に関する研究

第3編 脳の燐酸代謝におよぼす種々薬物の影響について

抄録

With the purpose to study the influences of chlorpromazine and cardiazol on the phosphoric acid metabolism of the brain the author studied the changes in the mode of the migration of ³²P that had been previously injected into the cisterna magna of test animals (rabbits). As the results it has been found that the phosphoric acid metabolism in the brain is generally inhibited by the chlorpromazine administration, especially ³²P migration to phospholipid fractions is markedly suppressed. And by the cramp due to cardiazol administration the amount of ³²P migrating to acid-soluble fractions both organic and inorganic is increased, while the same to phospholipid fraction, nucleic acid fraction and phosphoprotein fraction is decreased.