Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
Online ISSN : 1882-4528
Print ISSN : 0030-1558
Studies on the Serum Bilirubin of the Lungtuberculosis Patients
Part III The influences the Administration of hemoglobin, Glucose and Others on the Metabolism of Bilirubin
Masaru Ishiko
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1958 Volume 70 Issue 3 Pages 871-878

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Abstract
I have studied the prosperity and decay of the serum bilirubin in the lungtuberculosis patients with the oral administration of 4g hemoglobin or the intravenous administration of 20% Glucose 20 cc daily for 10 days. The results are as follows: At the same time, the results of other several experiments are added.
(1) The total serum bilirubin become temporally increased about 5 hours after the administration of hemoglobin in both healty persons and patients.
(2) The total serum bilirubin of the lungtuberculosis patients with the administration of hemoglobin shows the most low level in the severe cases and it is parallel to the cases without the administration in the standpoint of the breadth of the pathogenic tissue. Judging from the congo-red index, it is high at below the 49, and is almost same at over the 49.
(3) The congo-red index is not changed after the administration of glucose, while the total serum bilirubin become remarkably decrased in the severe cases.
(4) The total serum bilirubin become increased by the administration of hemoglobin at the both periods befere and after the administration of glucose and it shows a little high level at the periods after the administration of glucise, but it become decreased with the widening of pathogenic tissue, especially remarkable in the severe cases. But the increased level of the serum bilirubin by the administration of hemoglobin is remarkable in the cases with administration of glucose especially in the severe cases, as the serum bilirubin in the cases without the administration of hemoglobin become decreased by the administration of glucose.
(5) In the sever cases of lungtuberculosis, the dosis of blood plasma shows increased and it is thought as one of causes for hypobilirubinemia.
(6) Temporary hypobilirubinemia occurs by the administration of INAH, but it's cause is still obscure.
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