Action of Alkylphosohates on the Function of the Circulatory System

Part 1. Electrocardiographic Studies of Parathion Poisoning

Abstract

By examining the electrocardiograms from the patients and experimental animals of Parathion poisoning, the author obtained the following results:
1. Out of six patients with acute (manifested) Parathion poisoning there one with a decrease in ST segment and with a complication of the Adams-Stokes syndrome due to the disturbances in the auriculo-ventricular conduction.
2. In the latent cases of poisoning an elevation in T-wave could be observed.
3. Of the acute cases of experimental animals with a sinus bradicardia, an elevation in T-wave, a prolongation of PQ interval and auriculo-ventricular blocking were observed.
4. In chronic cases of experimental rabbits an elevation in T-wave could be observed.
5. These pathological changes mentioned above appear to be due to the action of acetylcholine accumulated by Parathion poisoning.