Studies on the Metabolism of Iron and Copper in Hypoplastic Anemia

Part 3. Stadies on the Effect of the Toxic Factor (Anemia-Inducing Substance) in the Serum of the Patient with Hypoplastic Anemia on the Non-Hemin Iron in Rabbit Viscera using the Radioactive Iron

Abstract

After the intravenous injection of the radioactive iron to the rabbits previously administered with the serum of patient with hypoplastic anemia, the radioactivity and the specific radioactivity on each fraction of the visceral non-hemin iron were evaluated. The results are as follows:
1. When the radioactive iron is injected intravenously, it is quite readily mobilized, without being mixed with the indigenous depot iron existing in the viscera.
2. The rate of metabolism in such fractions is most rapid in the fraction III, followed by fractions II and I, in that order; but the metabolism in fraction IV shows no fixed trend.
3. It has been confirmed that there exist in the serum of the patient with hypoplastic anemia factors disturbing the hematopoietic functions of the rabbit bone marrow.
4. The surplus iron not mobilized is stored is stored in viscera in the same order as mentioned above, namely, first in fraction III followed by fractions II and I.