Abstract
Experiment of citrate infusion was performed on dogs, and obtained following results.
1) Serum calcium and calcium-ion were increased, probably becaus of release of tissue calcium into blood.
2) Bleeding time was slightly prolonged, but clotting time was rather reduced.
3) Platelets count tended to be increased.
4) Prothrombin concentration was slightly decreased but no fibrinolysis was observed in all cases. No significant changes were observed in fibrinogen, recalcification time, thrombin time and prothrombin conversion time.
5) Liver function tests (B. S. P., and protein metabolism test) showed slight disorder in liver function.
6) From the facts above, it was concluded that infusion of citrate has not resulted in hemorrhagic tendency.
