Abstract
With the purpose to clarify the effect of antibiotics on the hematopoietic function of the bone marrow, especially on the leucocyte series, the author observed the effects of direct addition of various antibiotics on the tissue growth area and cell density of the bone marrow by performing rabbit bone-marrow tissue culture (cover-slip method); and obtained the following results:
1. Any one of antibiotics such as penicillin, dihydrostreptomycin, chloromycetin, aureomycin, achromycin, carzinophilin, actinomycin, and sarkomycin, at a higher concentration than a certain fixed concentration acts inhibitorily on the cell growth of the bone marrow.
2. Antibiotics such as penicillin, dihydrostreptomycin, aureomycin, and achromycin at the concentration close to the maximal concentration to blood as conventionally used in clinics all have no toxic effects, but some of them give a favorable influence on the cell growth of bone marrow, though slight.
3. As for chrolomycetin, actinomycin, carzinophilin and sarkomycin, they all act as to inhibit the bone-marrow tissue growth even at a relatively low concentration.
