Abstract
In order to elucidate the effect of antibiotics on the hematopoietic function of the bone marrow, especially on the leucocyte series, as a follow-up study of Part 1, the author studied the effects of various antibiotics on the function of mature pseudoeosinophils in the rabbit bone marrow, especially on the wandering velocity, carbon-particle phagocytosis, and vital staining, by means of bone-marrow tissue culture; and obtained the following results.
1. Antibiotics added to the bone-marrow tissue culture at a concentration higher than a certain fixed concentration all act as to inhibit the pseudoeosinophil function, and this tendency is marked in the case of antibiotics for cancer. In addition, chloromycetin tends to inhibit the function even at a relatively low concentration.
2. At a fixed low concentration including the maximal concentration, to blood penicillin, dihydrostreptomycin, aureomycin and achromycin all act as to promote the hematopoietic function rather than inhibiting it. This seems to indicate that leucocytes play an important role in the mechanism of cure of the bacterial infection due to antibiotics.
